Hormones, Plasticity & Stress.

11.08.2020: A new review from the lab is published:

Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks

Damien Huzard, Virginie Rappeneau, Onno C. Meijer, Chadi Touma, Margarita Arango-Lievano, Michael J. Garabedian and Freddy Jeanneteau.

The diversity of actions of the glucocorticoid stress hormones among individuals and within organs, tissues and cells is shaped by age, gender, genetics, metabolism, and the quantity of exposure. However, such factors cannot explain the heterogeneity of responses in the brain within cells of the same lineage, or similar tissue environment, or in the same individual. Here, we argue that the stress response is continuously updated by synchronized neural activity on large-scale brain networks. This occurs at the molecular, cellular and behavioral levels by crosstalk communication between activity-dependent and glucocorticoid signaling pathways, which updates the diversity of responses based on prior experience. Such a Bayesian process determines adaptation to the demands of the body and external world. We propose a framework for understanding how the diversity of glucocorticoid actions throughout brain networks is essential for supporting optimal health, while its disruption may contribute to the pathophysiology of stress-related disorders, such as major depression, and resistance to therapeutic treatments.Keywords: Allosteryepigeneticplasticitysynapsestress-related disordersBayesian brain

Two new articles from the lab:

1) Regeneration of the neurogliavascular unit visualized in vivo by transcranial live-cell imaging
Congrats to the authors: Arango-Lievano M*, Dromard Y*, Fontanaud P*, Lafont C, Mollard P and Jeanneteau F
Published in the Journal of Neuroscience Methods.

2) The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility.
Sánchez-Huertas C, Bonhomme M, Falco A, Fagotto-Kaufmann C, van Haren J, Jeanneteau F, Galjart N, Debant A, Boudeau J. J Cell Biol. 2020 Sep 7;219(9):e201905199.

PORTRAIT du laboratoire sur le site de la Fondation pour la Recherche Médicale (FRM): Lien ICI

Crédit @FRM

Photo by Jukan Tateisi

INTERVIEW of Freddy for LePoint.fr (FR): ” Les inquiétantes conséquences à long terme du stress précoce

Overview of our research:

We are studying the systems and neuronal networks implicated in the regulation of behaviors in mice models.

Two-Photon Imaging

Photo by Nicolas Six

Our lab uses a variety of technologies in order to determine the circuitry regulating social behaviors (link), memory formation (link) and …

(Photo by Nicolas Six)

The Live Mouse Tracker

Photo by Nicolas Six

We use the Live Mouse Tracker, an open-source technology, to study social behaviors of groups of mice.

(Photo by Nicolas Six)

Mice house in groups display a complex range of natural and social behaviors.